IO Interactive has stated that players will see "a globetrotting Agent 47 at the prime of his career - the apex predator stalking his prey across the world, with the support of his long-term handler Diana Burnwood and the whole of the ICA."
IO seems to be focusing majorly on the reasons that made Hitman stand apart from it's competitors, and that of course comes down to the wide range of weapons that can be used to take out targets. Whether it's a playing card or the shoe off of your victim's feet, it's usually possible on Hitman, and IO are banking on this concept for the success of the next Hitman.
IO are hoping to go back to their roots and make the game feel more like the original than 2012's title.
"We've adopted an open, non-linear level design approach to the game, ensuring the game will play out across huge, checkpoint-free, sandbox levels. Our aim is to create living, breathing and believable levels which will allow gamers to play around with the AI to create those unique moments every fan of the Hitman franchise loves."
I expect the next Hitman will be released some time in 2015, but no details have been given on a release window, yet.